Biosynthesis-assisted Structure Elucidation of Colibactin, the Genotoxic Metabolite Produced by Commensal Microbiota

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  • 21世紀における構造未決定天然物 大腸発がんリスク因子コリバクチンの生合成
  • 21セイキ ニ オケル コウゾウ ミケッテイ テンネンブツ ダイチョウ ハツガン リスク インシ コリバクチン ノ セイゴウセイ

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Abstract

<p>Colibactin, a secondary metabolite produced by a commensal Escherichia coli harboring pks island, exhibits a genotoxicity to mammalian cells and progresses to colorectal cancer. Regardless of potential risk for the promotion of cancer by colibactin, which shows neither a biological mechanism of action nor determination of chemical structure. Analysis of a genetic mutant of colibactin-producing E. coli enabled us to provide biosynthetic intermediates and shunt products associated with a partial structure of colibactin. This review covers the recent findings of the biosynthesis and implication of chemical structure of colibactin.</p>

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