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- 吉田 雅紀
- 旭川工業高等専門学校一般理数科
書誌事項
- タイトル別名
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- Catalytic Asymmetric Synthesis with a Primary Amino Acid and Its Salt
- ダイイチキュウ アミノサン オヨビ ソノ シオ オ モチイタ ショクバイテキ フセイ ゴウセイ
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Readily obtainable primary α- and β-amino acid lithium salts were found to be efficient catalysts for iminium-enamine-type asymmetric organocatalyses. By using <SC>L</SC>-phenylalanine lithium salt as a catalyst, asymmetric Michael addition of α-branched aldehydes to nitroalkenes was achieved via the formation of enamines to obtain synthetically useful γ-nitroaldehydes possessing a quaternary carbon stereogenic center in high yields with high enantioselectivity. On the other hand, highly enantioselective Michael addition of malonates to enones was successfully carried out by the iminium catalysis using a mixed catalyst consisting of a primary β-amino acid, O-tert-butyldiphenylsilyl (S)-β-homoserine, and its lithium salt. Details of the studies regarding to the organocatalyses using primary α- and β-amino acid lithium salt-catalysts including substrate scopes and mechanistic studies are described.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 72 (8), 876-889, 2014
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390001205339441920
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- NII論文ID
- 130004691488
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 025749941
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 使用不可