二量体型モノテルペンインドールアルカロイド(+)-Haplophytineの合成研究

DOI Web Site Web Site 参考文献18件

書誌事項

タイトル別名
  • Synthetic Studies on Dimeric Monoterpene Indole Alkaloid: (+)-Haplophytine
  • ニリョウ タイケイ モノテルペンインドールアルカロイド(+)-Haplophytine ノ ゴウセイ ケンキュウ

この論文をさがす

抄録

<p>Since dimeric indole alkaloids possess architectural diversities and a wide range of biological activities, development of new synthetic strategies for construction of these structures has been one of the important topics in synthetic chemistry. Among these compounds, we focused on an architecturally intriguing dimeric monoterpene indole alkaloid, (+)-haplophytine, which had remained an unanswered challenge for more than a quarter century in the area of alkaloid synthesis. Our first total synthesis and the second generation synthesis of (+)-haplophytine are described. The synthesis of this dimeric compound features Ag-mediated coupling reaction between two polycyclic fragments. In addition, the characteristic diazabicyclo[3.3.1] skeleton in left segment was constructed by means of creative skeletal rearrangement including oxidation step.</p>

収録刊行物

参考文献 (18)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ