書誌事項
- タイトル別名
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- Natural Product Synthesis by Multicomponent Reaction and Structure-activity Relationship Study
- タセイブン ハンノウ オ モチイタ テンネンブツ ゴウセイ ト コウゾウ カッセイ ソウカン ケンキュウ
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説明
Multicomponent reaction represented by Mannich reaction, Strecker reaction and Biginelli reaction has been applied to several natural product synthesis because a complexed framework of the natural product can be constructed by assembling more than three simple components at one step. It is also attractive from a medicinal chemical point of view because it enables us to supply a range of analogues to investigate a structure-activity relationship simply by changing components in the reaction. Here, we described our recent studies utilizing a multicomponent reaction in natural product-based medicinal chemistry. First topic is about total synthesis of syringolin A class of proteasome inhibitor and its structure-activity relationship study by intramolecular Ugi three-component reaction. We also synthesized cyclic peptide natural products (sandramycin, quinaldopeptin) and analogues and revealed their biological properties. Finally, design and synthesis of simplified caprazamycin analogues using aza-Prins-Ritter reaction was described.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 74 (5), 426-440, 2016
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390001205339612544
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- NII論文ID
- 130005159415
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 027428422
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
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- OpenAIRE
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- 使用不可