糖タンパク質化学合成法の開発とその機能解析への応用

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  • Toward the Understanding of Glycoprotein through Chemical Synthesis
  • トウ タンパクシツ カガク ゴウセイホウ ノ カイハツ ト ソノ キノウ カイセキ エ ノ オウヨウ

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<p>Carbohydrates on proteins play various essential biological roles, such as fertilization, cell adhesion, cell differentiation. However, to understand these biological processes in more detail, proteins with homogeneous carbohydrate are required. The glycan chains of natural glycoproteins are highly heterogeneous, as they are formed by the action of various glycosyl transferases and glycosidases without appropriate templates. On the other hand, expression system using E. coli can not produce glycoproteins, as it does not have glycosylation machinery. These facts result in the lack of an efficient access to homogeneous glycoproteins, which makes the functional analysis of glycoproteins difficult. Due to the recent advances of peptide and glycoscience, the chemical synthesis of homogeneous glycoproteins has become practical. In this paper, I describe recent results of our glycoprotein synthesis.</p>

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