書誌事項
- タイトル別名
-
- Chemical Synthesis of Zoanthamine Alkaloids
- ゾアンタミンアルカロイド ノ カガク ゴウセイ
この論文をさがす
抄録
The zoanthamine alkaloids isolated from the genus Zoanthus species during the last three decades constitute a distinctive family of marine metabolites. These natural products are characterized by the densely functionalized heptacyclic framework, as exemplified by the structures of norzoanthamine (1), zoanthamine (2), and zoanthenol (3), as well as their potent spectrum of unique biological properties such as promising antiosteoporotic properties. Their distinctive biological activities, combined with novel chemical structures, make this family of alkaloids extremely attractive targets for chemical synthesis. However, because of their densely functionalized complex structures, synthetic studies of zoanthamine alkaloids had seriously been impeded until we reached the first total synthesis of norzoanthamine. We describe herein our synthetic approach toward the total synthesis of zoanthamine alkaloids (1-3), focusing on how to tackle and overcome various synthetic challenges.
収録刊行物
-
- 有機合成化学協会誌
-
有機合成化学協会誌 71 (2), 124-135, 2013
公益社団法人 有機合成化学協会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001205340427264
-
- NII論文ID
- 10031148204
-
- NII書誌ID
- AN0024521X
-
- COI
- 1:CAS:528:DC%2BC3sXjsFGjsr0%3D
-
- ISSN
- 18836526
- 00379980
-
- NDL書誌ID
- 024278278
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可