書誌事項
- タイトル別名
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- Synthetic Potential of Configurationally Unstable Chiral Carbanions
- リッタイ カガクテキ ニ フアンテイ ナ キラルカルバニオン ノ ゴウセイ カガク エ ノ テンカイ
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This account presents our recent efforts in exploring the synthetic potential of configurationally labile chiral carbanions next to electron-withdrawing groups that have been considered to be impossible even to generate. We used epoxysilane rearrangement to generate a chiral carbanion whose chirality was transformed from epoxide. The detailed analysis of the process showed that a carbamoyloxy group plays a more prominent role in fixing a chiral lithiocarbanion than expected. This understanding has led to the successful development of a method that allows enantioselective trapping of an α-chiral carbanion of acyclic nitrile by a carbon electrophile. During the course of these studies, we have found that the configurational stability of a carbanion highly depends on the solvent and we have proposed that the dependency is attributable to the ratio of CIP and SIP associated with their solvated structures.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 71 (2), 136-148, 2013
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390001205340428544
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- NII論文ID
- 10031148205
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BC3sXjsFGjsro%3D
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 024278306
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可