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- 波多野 学
- 名古屋大学大学院工学研究科
書誌事項
- タイトル別名
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- Design of Tailor-Made Conformationally Flexible Chiral Supramolecular Catalysts Beyond Enzymes
- コウソ オ リョウガ スル テーラーメイドガタハイザジュウナンセイ キラル チョウブンシ ショクバイ ノ セイミツ セッケイ
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To surpass enzymes, the potential of supramolecular catalysts to realize anomalous stereoselectivity in organic synthesis is highly attractive. However, to date, there have been a few examples of non-polymeric and non-covalent chiral supramolecular catalysts that induce both practical yield and excellent stereoselectivity. To establish high catalytic activity with anomalous stereoselectivity, in principle, an artificial cage should be conformationally flexible, like an active pocket in an enzyme with an induced-fit function. In this article, we focus on the anomalous endo/exo-selective enantioselective Diels-Alder reaction, and show the development of the successive catalysts including our recent highly active, conformationally flexible, and chiral supramolecular catalysts. The evolution from ‘ready-made’ single-molecule catalysts to ‘tailor-made’ supramolecular catalysts could offer not only high enantioselectivity but also high anomalous endo/exo-selectivity due to substrate-specific characteristics, as with enzymes.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 70 (12), 1242-1254, 2012
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390001205341022848
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- NII論文ID
- 10031137475
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BC38XhvVOitbvN
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 024148404
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 使用不可