Electrophysiologic and hemodynamic effects of SUN 1165. A study in patients with supraventricular tachycardia.
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- INO Takeshi
- The First Department of Internal Medicine, Nippon Medical School
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- ATARASHI Hirotsugu
- The First Department of Internal Medicine, Nippon Medical School
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- SAITOH Hirokazu
- The First Department of Internal Medicine, Nippon Medical School
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- KOBAYASHI Yoshinori
- The First Department of Internal Medicine, Nippon Medical School
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- ONODERA Takeo
- The First Department of Internal Medicine, Nippon Medical School
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- KUROKI Shin-ichi
- The First Department of Internal Medicine, Nippon Medical School
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- KAMEI Shin-ichirou
- The First Department of Internal Medicine, Nippon Medical School
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- YASHIMA Masa-aki
- The First Department of Internal Medicine, Nippon Medical School
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- KURUMA Akinori
- The First Department of Internal Medicine, Nippon Medical School
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- HAYAKAWA Hirokazu
- The First Department of Internal Medicine, Nippon Medical School
Bibliographic Information
- Other Title
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- SUN1165単回経口投与の電気生理学的効果ならびに心血行動態に及ぼす影響―発作性上室性頻拍例における検討
- A Study in Patients with Supraventricular Tachycardia
- 発作性上室性頻拍例における検討
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Abstract
SUN 1165 is a newly synthesized antiarrhythmic drug with class Ic properties in vitro.We assessed acute electrophysiologic and hemodynamic effects of SUN 1165 in 18 patientswith supraventricular tachycardia (SVT) [6 patients with AV nodal reentrant tachycardia (AVNRT), and 12 patients with AV reentrant tachycardia (AVRT)]. All patients werefree from organic heart disease. Electrophysiologic and hemodynamic studies were performedbefore and 60 min after a single oral administration of SUN 1165 (150 or 200 mg).SUN 1165 significantly shortened sinus cycle length, lengthened sinoatrial conductiontime (98±21 to 112±21 msec, P< 0.01), AH interval (83±11 to 100±15, P<0.01), HVinterval (42±8 to 63±17, P<0.001), and RV effective refractory period (220±28 to 231±27, P<0.05).Antdrograde conduction via accessory pathway (AP) was abolished in 6out of 7 patients. Retrograde conduction via AP and AV node were abolished in 9 out of12 and 2 out of 6 patients respectively. Induction of SVT was completely suppressed in9 out of 13 patients. By hemodynamic studies (10 patients), decrease of stroke volumeindex and increase of mean pulmonary arterial pressure were demonstrated. No adverseeffects were observed. In conclusion, oral SUN 1165 has potent electrophysiologic effectson impulse propagation through AV node and AP with mild negative inotropic action. Andthe suppression of SVT induction was mediated through predominant effect on retrogradeconduction.
Journal
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- Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
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Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 20 (4), 677-685, 1989
The Japanese Society of Clinical Pharmacology and Therapeutics
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Details 詳細情報について
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- CRID
- 1390001205341119616
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- NII Article ID
- 130002046386
- 80004960466
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- ISSN
- 18828272
- 03881601
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed