書誌事項
- タイトル別名
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- From Chiral Base Catalysts to Redox-Active Catalysts: Chasing the Identity of Metal Catalysts in Carbon-Carbon Bond-Forming Reactions
- キンゾク ショクバイ コユウ ノ トクセイ オ イカシタ タンソ-タンソ ケツゴウ ケイセイ ハンノウ オ メザシテ : エンキ ショクバイ カラ レドックス カッセイ ショクバイ エ
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In general, biologically active drug lead molecules are structurally complex, bearing multiple functional groups and chiral sp3 carbons. Our aim in developing new catalysis is to promote a concise, robust, and clean drug lead synthesis. To do so requires catalysis allowing for the design of concepually new retrosynthesis independent of functional groups. Here we summarize our first step toward such a goal. First, we describe a Cu(I)-catalyzed enantioselective condensation of ketones and hemiaminals that can produce versatile chiral building blocks for alkaloid synthesis. The hard anion-conjugated soft metal (HASM) catalysis concept is the basis for the reactivity. Second, two Cu-catalyzed cross-dehydrogenative coupling (CDC) reactions are discussed. The radical-conjugated redox catalysis (RCRC) concept leads to the development of a very early example of catalytic asymmetric aerobic CDC. Third, the Rh-catalyzed aldehyde cross aldol reaction and the Co-catalyzed C-4 selective alkylation of pyridines, both of which are mediated by means of hydride transfer, are described. Unique reactivity in the latter two topics is partly due to the redox activity of the transition metal catalysts.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 71 (5), 433-442, 2013
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390001205341136640
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- NII論文ID
- 10031171534
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BC3sXosVOrtr0%3D
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 024663732
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- KAKEN
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- 抄録ライセンスフラグ
- 使用不可