Antimicrobial and Antibiofilm Effects of Ozonated Water for Prevention and Treatment of Bone and Joint Infections
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- Koyama Ryouta
- Department of Orthopaedic Surgery, St. Marianna University School of Medicine
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- Okuda Ken-ichi
- Department of Bacteriology, The Jikei University School of Medicine
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- Matsushita Kazuhiko
- Department of Orthopaedic Surgery, Kawasaki Municipal Tama Hospital
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- Beppu Moroe
- Department of Orthopaedic Surgery, St. Marianna University School of Medicine
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- Mizunoe Yoshimitsu
- Department of Bacteriology, The Jikei University School of Medicine
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Abstract
Antimicrobial effects of ozonated water for the planktonic cells and the biofilm cells of staphylococci were examined for clinical applications in the orthopaedic field. As a result, 7 mg/L of ozonated water showed antimicrobial effects for not only the planktonic cells but also for the biofilm cells. Additionally, antimicrobial activity of ozonated water was examined after destroying the biofilm using 1 M NaCl or proteolytic enzymes (proteinase K and trypsin). Interaction between ozonated water and biofilm destruction was statistically significant in 2 strains (SE21, MR23) out of 8 strains. However, the effects of proteinase K or trypsin with ozonated water were statistically significant only in MRSA MR23. MRSA MR23 was previously reported to be a proteinaceous biofilm producer, and its biofilm was destructed by various proteases.
Journal
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- Journal of St. Marianna University
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Journal of St. Marianna University 6 (1), 1-7, 2015
St. Marianna University Society of Medical Science
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Details 詳細情報について
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- CRID
- 1390001205350602880
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- NII Article ID
- 130005085601
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- NII Book ID
- AA12479475
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- ISSN
- 21890277
- 21851336
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- NDL BIB ID
- 026602722
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed