γチューブリンとその関連タンパクの種多様性
-
- 紅 朋浩
- 名古屋大学大学院医学研究科付属病態制御研究施設医真菌研究部門
書誌事項
- タイトル別名
-
- Divergencies of γ-tubulin and γ-tubulin-related proteins
説明
Summary: The third tubulin, γ-tubulin, is the most general component of microtubule organizing center(MTOC). Many data have been indicating that γ-tubulin has an essential role for the establishment of microtubule(MT)network. Recent studies have also revealed that γ-tubulin in vivo is not monomeric but exists as a constituent of huge protein complex(es). The most famous complex is γ-tubulin-ring complex(γTuRC)in animal cells. We analysed cytoplasmic γ-tubulin of a fungus, Aspergillus nidulans, and revealed that there are divergent γ-tubulin complexes in this organism. Current knowledge about γ-tubulin biogenesis supports the idea that more than one form of γ-tubulin complexes exist in the cells. Divergency is also seen in γ-tubulin itself. The typical example is γ-tubulin of the budding yeast Saccharomyces cerevisiae. In order to clarify the nature of the divergency, we analysed the sequences of other budding yeast γ-tubulins and found that the divegency spreads among the yeasts. Detailed comparison of the sequences, however, indicated a conservative nature of γ-tubulin; the divergent γ-tubulins still preserve the same or similar amino acids important for rtubulin. The analysis also revealed a feature characteristic to the budding yeast γ-tubulins; a number of amino acids conserved uniquely in them seemed to locate in the molecular surface corresponding to the minus-end of tubulin structure. Furthermore, some of the yeast-specific amino acids seemed to be involved in the nuclear localization of the γ-tubulin. In this review, I also discuss divergencies of γ-tubulin and its related proteins as research objects to know the journey of the MT organizer to its functional maturation.
収録刊行物
-
- PLANT MORPHOLOGY
-
PLANT MORPHOLOGY 13 (1), 21-30, 2001
日本植物形態学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205357741056
-
- NII論文ID
- 130004303761
-
- ISSN
- 18844154
- 09189726
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可