Investigations were made to determine the effects of bathing on the body metabolism of alcohol and its intermediary metabolite, acetaldehyde. The experiments were made using rabbits. Results were as follows:<br>1) In 20 minutes bathing in water of 23°C or 45°C immediately after the intake of 1g. per kg. of alcohol by stomach tube, the blood alcohol levels for the first 2 hours were lower significantly than those of control (alcohol alone) and thereafter no signicant changes were observed. On the other hand, acetaldehyde blood levels were lower than those of control for the first 2 hours after alcohol intake and thereafter higher than control. In the bathing in water of 38°C, there were no significant changes cone erning them eta-bolic rate of alcohol and acetaldehyde.<br>2) In 20 minutes bathing in water of 45°C or 23°C 1 hour after alcohol intake, the rate of disappearance of alcohol from the blood was significantly delayed during and 30 minutes after the bathing. Acetaldehyde blood levels were higher than those of control in 2 to 6 hours following alcohol ingestion. In the bathing in water of 42°C, the rate of disappearance of alcohol from the blood was slightly accelerated while acetaldehyde blood levels were unchanged. In 60 minutes bathing in water of 39°C after the oral administration of 2g. per kg. of alcohol, its blood levels were lower than those of control for the first 3 hours.<br>3) In 20 minutes bathing in water of 45°C or 38°C or 23°C after intravenous injection of 1g. per kg. of alcohol, the rate of disappearance of alcohol from the blood was slightly delayed while in water of 42°C it was slightly acceleratad. Acetaldehyde blood levels were unchangeable in all the cases.<br>4) In 60 minutes bathing in water of 39°C after 1/2 hour and 4 hours following the injection of 2g. per kg. of alcohol, the metabolic rate of it tended to be delayed.<br>5) In 20 minutes bathing in water of 39°C from 5 minutes after the intravenous administration of 50mg. per kg. of acetaldehyde, the rate of disappearance of it from the blood decreased significantly in 60 to 90 minutes following its administration.<br>6) When rabbits pretreated with Disulfiram received 50mg. per kg. of acetaldehyde intravenously and 5 minutes later were put into the bath in water of 39°C for 20 minutes, the rate of elimination of acetaldehyde was significantly delayed.<br>7) In 20 minutes bathing in water of 39°C from 15 minutes after the intravenous administration of 1g. per kg. of alcohol and 100mg. per kg. of acetaldehyde at the same time, no significant changes in metabolic rate of alcohol were noted while acetaldehyde blood levels remained significantly higher, compared with the control.