石膏の薬理学的研究

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タイトル別名
  • Pharmacological studies of crystalline gyps of natural origin being used in Oriental medicine.
  • セッコウ ノ ヤクリガクテキ ケンキュウ 5 セッコウ セイザイ カンヤク ノ
  • Part 5. Properties of several kinds of Kampo-recipes which contain the gyps, and their pharmacological effects on the bufo's heart and on the blood pressure and bile flow in the rats and cats
  • 第5部石膏製剤漢薬の性状と2・3の薬理作用

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In the present study, Dai-Sei-Ryu-To, Chiku-Yo-Sekko-To, Byakko-Ka-Ninjin-To, Eppi-Ka-Jutsu-To, Ma-Kyo-Kan-Seki-To, Byakko-Ka-Keihi-To, and Moku-Boi-To which compound the gyps were used. Warm-infusions of the drugs were prepared by steeping a day-dosage of each drug in the distilled water of 100 mlat 90°C for 30 minutes. The results obtained were summarized as follows:<BR>1) Warm-infusion with the heighest Ca concentration or electric conductivity was Dai-Sei-Ryu-To (50.5mg/dl) or Byakko-Ka-Keihi-To (583Ωcm), and that with the lowest Ca or electric conductivity was Moku-Boi-To (18. 6 mg/dl) or Dai-Sei-Ryu-To (223Ωcm). SO4- was contained in each of all warm infusions, and pH of them ranged from 4.0 to 5.0.<BR>2) The movements of isolated bufo's heart were inhibited with each warm-infusion, but restored to the former condition after replacing it with Ringer solution.<BR>3) Amounts of bile flow of rats and cats increased with Moku-Boi-To, Byakko-Ka-Keihi-To and Chiku- Yo-Sekko-To, and decreased with Dai-Sei-Ryu-To.<BR>4) Blood pressure of rats and cats rose slightly by the small dose of warm-infusions, and fell by the large dose of them.

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