Causative Agents of Aspergillosis Including Cryptic <I>Aspergillus</I> Species and <I>A. fumigatus</I>

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  • Toyotome Takahito
    Obihiro University of Agriculture and Veterinary Medicine Diaghostic Center for Animal Health and Food Safety Division of Clinical Research, Medical Mycology Research Center, Chiba University

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  • 原因真菌から見たアスペルギルス症
  • ゲンイン シンキン カラ ミタ アスペルギルスショウ

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Abstract

Aspergillosis is an important deep mycosis. The causative agents are Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, and Aspergillus terreus, of which A. fumigatus is the most prevalent. Cryptic Aspergillus spp., which morphologically resemble representative species of each Aspergillus section, also cause aspergillosis. Most of the cryptic species reveal different susceptibility patterns and/or different secondary metabolite profiles, also called exometabolome in this manuscript, from those representative species. On the other hand, azole-resistant A. fumigatus strains in clinical specimens and in the environment have been reported. Therefore, it is imperative to precisely identify the species, including cryptic Aspergillus spp., and evaluate the susceptibility of isolates.<BR>In this manuscript, some of the causative cryptic Aspergillus spp. are briefly reviewed. In addition, the exometabolome of Aspergillus section Fumigati is described. Finally, azole resistance of A. fumigatus is also discussed, in reference to several studies from Japan.

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