Bibliographical Investigation (Domestic and Overseas) on the Treatment of Endogenous <I>Candida</I> Endophthalmitis over an 11-Year Period

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  • Hamada Yukihiro
    Department of Pharmacy, Kitasato University East Hospital
  • Okuma Ryota
    Pharmacy Practice and Science II (Kitasato University East Hospital), School of Pharmacy, Kitasato University
  • Katori Yusuke
    Department of Pharmacy, Kitasato University East Hospital
  • Takahashi Saki
    Pharmacy Practice and Science II (Kitasato University East Hospital), School of Pharmacy, Kitasato University
  • Hirayama Takeshi
    Department of Pharmacy, Kitasato University East Hospital Pharmacy Practice and Science II (Kitasato University East Hospital), School of Pharmacy, Kitasato University
  • Ichibe Yoshiaki
    Department of Ophthalmology, Kitasato University School of Medicine
  • Kuroyama Masakazu
    Department of Pharmacy, Kitasato University East Hospital Pharmacy Practice and Science II (Kitasato University East Hospital), School of Pharmacy, Kitasato University

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  • Bibliographical Investigation (Domestic and Overseas) on the Treatment of Endogenous Candida Endophthalmitis over an 11-Year Period

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Abstract

A bibliographic search was conducted of cases of Candida endophthalmitis reported in Japan and overseas between 2000 and 2011, in the Japana Centra Revuo Medicina Website of Japan Medical Abstracts Society (domestic reports) and MEDLINE (overseas reports). The investigation yielded 42 reports in domestic journals (49 cases ; hereinafter referred to as domestic cases) and 39 reports in journals published overseas (46 cases ; hereinafter referred to as overseas cases). The isolation rate of Candida albicans in the domestic cases was 65.3%, and that in the overseas cases was 71.7%. The initial treatment for the Candida endophthalmitis was fluconazole (FLCZ) therapy in 51.0% of the domestic cases and 38.1% of the overseas cases. Domestic reports suggested the effectiveness of FLCZ therapy for stage II cases, and of vitrectomy for stage III and IV cases. Reports from overseas, on the other hand, suggested the effectiveness of amphotericin B (AMPH-B) or voriconazole (VRCZ) therapy for stage II cases, and of vitrectomy for stage III and IV cases.

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