A Case of Liver Dysfunction Requiring Hospital Admission after Taking Oral Itraconazole for the Treatment of Kerion Celsi

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  • Ikeda Eri
    Department of Dermatology, Tokyo Women’ Medical University Medical Center East
  • Watanabe Soko
    Department of Dermatology, Tokyo Women’ Medical University Medical Center East
  • Sawada Mizuki
    Department of Dermatology, Tokyo Women’ Medical University Medical Center East
  • Ninomiya Junya
    Department of Dermatology, Tokyo Women’ Medical University Medical Center East
  • Dekio Itaru
    Department of Dermatology, Tokyo Women’ Medical University Medical Center East
  • Ishizaki Sumiko
    Department of Dermatology, Tokyo Women’ Medical University Medical Center East
  • Fujibayashi Mariko
    Department of Pathology, Tokyo Women’ Medical University Medical Center East
  • Tanaka Masaru
    Department of Dermatology, Tokyo Women’ Medical University Medical Center East
  • Harada Takashi
    Department of Dermatology, Tokyo Women’ Medical University Medical Center East Harada Dermatology Clinic

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Other Title
  • イトラコナゾール内服によるケルスス禿瘡加療中に入院を要する肝障害をきたした1例
  • イトラコナゾール ナイフク ニ ヨル ケルスス ハゲソウカリョウ チュウ ニ ニュウイン オ ヨウスル カン ショウガイ オ キタシタ 1レイ

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Abstract

  67-year-old female patient developed drug-induced liver dysfunction after taking oral itraconazole (ITCZ) for the treatment of kerion celsi. Red papules appeared on the temporal area of the patient one month prior to her visit to our clinic. The patient presented with a nodule with yellow crust, erosion, infiltration, and hair loss on the area. Diagnosis of kerion celsi caused by Trichophyton rubrum was made from clinical, pathological, and mycological findings. Laboratory data showed normal liver function, and the patient was not taking any other medication, thus, daily oral ITCZ 100 mg was started. The skin lesion improved, but severe liver dysfunction was found 1 month after starting ITCZ. Oral ITCZ was therefore terminated, and the patient was admitted to a medical ward for the treatment of liver dysfunction. Hepatobiliary enzymes increased after admission: AST 232 IU/L, ALT 465 IU/L, T-bil 6.1 mg/dL, and D-bil 3.9 mg/dL. The patient was kept at rest and was given oral ursodeoxycholic acid. Hepatobiliary enzymes returned to normal level 2 1/2 months after starting ITCZ. The skin lesion healed without further treatment. No recurrence was observed. It is noteworthy that liver function has to be carefully monitored during treatment with oral ITCZ.

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