Influence of Different Probiotic Lactic Acid Bacteria on Microbiota and Metabolism of Rats with Dysbiosis

DOI Web Site 参考文献63件
  • ERMOLENKO Elena
    Department of Molecular Microbiology, Institute of Experimental Medicine, Russia
  • GROMOVA Ludmila
    Department of Physiology of Nutrition, Pavlov Institute of Physiology, Russia
  • BORSCHEV Yuri
    Department of Physiology of Nutrition, Pavlov Institute of Physiology, Russia
  • VOEIKOVA Anna
    Department of Molecular Microbiology, Institute of Experimental Medicine, Russia
  • KARASEVA Alena
    Department of Molecular Microbiology, Institute of Experimental Medicine, Russia
  • ERMOLENKO Konstantin
    Laboratory of Immunology, Pasteur Institute of Epidemiology and Microbiology, Russia
  • GRUZDKOV Andrei
    Department of Physiology of Nutrition, Pavlov Institute of Physiology, Russia
  • SUVOROV Alexander
    Department of Molecular Microbiology, Institute of Experimental Medicine, Russia

この論文をさがす

説明

Lactic acid bacteria (LAB) are often used for prevention and treatment of dysbiosis. However, the action of various strains of LAB on metabolism and digestion under these conditions are poorly understood. The purpose of this study was to investigate the influence of probiotic LAB on metabolism, digestion and microbiota in animals with dysbiosis. After administration of ampicillin and metronidazole male Wistar rats, were fed products containing Enterococcus faecium L3 (E.f.), Lactobacillus fermentum Z (L.f.) or milk (control 1). Animals in control group 2 were fed milk, after water instead of antibiotics. Dyspeptic symptoms disappeared after administration of probiotic compared with control 1. At the end of the experiment, an increase in the content of enterococci and lactobacilli in the proximal part of the small intestine was found in the animals treated with E.f. and L.f., respectively. After the introduction of probiotic enterococci, the quantity of lactobacilli and bifidobacteria in the intestines of rats increased, and the content of Klebsiella spp. and Escherichia coli decreased in comparison with the control group 1 and the group fed lactobacilli. The activity of alkaline phosphatase and aspartate transaminase was greater in blood serum of rats with dysbiosis receiving milk and lactobacilli. Intestinal alkaline phosphatase activity increased in the epithelium and chyme in the jejunum of the animals treated with L. f. and in the chyme only in the animals treated with E. f. Thus, the specific effects of different strains of probiotic LAB on the microbiota, and on metabolism and digestion of various nutrients were demonstrated.

収録刊行物

参考文献 (63)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ