Molecular Imaging of Dementia

DOI
  • Suhara Tetsuya
    Molecular Imaging Center, National Institute of Radiological al Sciences
  • Higuchi Makoto
    Molecular Imaging Center, National Institute of Radiological al Sciences
  • Maeda Jun
    Molecular Imaging Center, National Institute of Radiological al Sciences
  • Ji Bin
    Molecular Imaging Center, National Institute of Radiological al Sciences

Bibliographic Information

Other Title
  • 認知症の分子イメージング

Abstract

Visualization of amyloid fibrils by in-vivo imaging techniques accordingly offers diagnostic information at a prodromal stage of the disease, and facilitates therapeutic evaluations during the course of emerging anti-amyloid treatments. By comparing findings in positron emission tomographic (PET) amyloid imaging of AD and model mouse brains, an N-terminally cleaved and modified Aβ termed AβN3 (pE) has been identified as a major constituent of “AD-like” Aβ plaques enriched with binding sites for imaging agents. Clarification of the molecular pathogenesis and development of diagnostic and therapeutic agents can synergistically promote each other with the aid of molecular imaging technologies. Other elements such as tau inclusions and activated microglia in living brains would be of vital significance.

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Details 詳細情報について

  • CRID
    1390001205412236928
  • NII Article ID
    130005395379
  • DOI
    10.11249/jsbpjjpp.21.4_261
  • ISSN
    21866465
    21866619
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
    • KAKEN
  • Abstract License Flag
    Disallowed

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