Activation in the prefrontal cortex during facial expression processing in pervasive developmental disorder using near-infrared spec-troscopy

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  • Nakadoi Yoshihiro
    Child psychiatry, Shikoku Medical Center for Children and Adults Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School
  • Watanabe Yukina
    Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School
  • Hosokawa Mai
    Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School
  • Sumitani Satsuki
    Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School
  • Ohmori Tetsuro
    Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School

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  • 広汎性発達障害における多チャンネル近赤外線スペクトロスコピーを用いた表情処理過程
  • コウハンセイ ハッタツ ショウガイ ニ オケル タチャンネル キン セキガイセン スペクトロスコピー オ モチイタ ヒョウジョウ ショリ カテイ

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Abstract

One of the most characteristic impairments in social communication in pervasive developmental disorders (PDD) is the failure to perceive and respond to non-verbal conversational cues such as facial expression. We found out that healthy subjects had significantly increased oxyHb changes during a processing task of fearful expression compared to happiness in the prefrontal cortex (PFC) and found significant correlations between oxyHb change in PFC and Autism-Spectrum Quotient score using near-infrared spectroscopy (NIRS). Moreover, we showed that 14 patients with PDD had significantly reduced oxyHb changes in PFC during a processing task of fearful expression compared to 14 age-and sex-matched healthy controls. NIRS could be one of the most powerful tools for PDD research, because it has advantages in convenience, non- invasiveness and less of psychological and physical burden.

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