Molecular mechanism of fatigue and mood disorders

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  • Kondo Kazuhiro
    Department of Virology, The Jikei University School of Medicine

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  • 疲労誘発因子と抗疲労因子：うつ病の疲労による誘発機構
  • ヒロウ ユウハツ インシ ト コウヒロウ インシ : ウツビョウ ノ ヒロウ ニ ヨル ユウハツ キコウ

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Human herpesvirus (HHV-) 6 is capable of establishing a lifelong latent infection of their host, is reactivated frequently. We are studying the molecular mechanism of latency and pathogenesis of HHV-6, and find SITH-1 a novel latent protein of HHV-6 which associate with mood disorders. Additionally we are trying to apply HHV-6 and HHV-7 to the tools for studying the mechanism of fatigue and to the viral vector for gene therapy. Fatigue is an indispensable bio-alarm to avoid the exhaustive state caused by severe stresses and overwork, which may also induce a variety of diseases. We have investigated the molecular mechanism of HHV-6 and HHV-7 reactivation that was known to be stimulated by fatigue, and identified the molecule that can induce viral reactivation during fatigue. Using the knowledge of herpesvirus reactivation, we have developed a method for measuring accumulation of fatigue by determining the amount of a HHV-6 and HHV-7, which is reactivated, and released into saliva.

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