Carbonyl stress dysfunction in a subpopulation of schizophrenia

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  • Arai Makoto
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
  • Kobori Akiko
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
  • Miyashita Mitsuhiro
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
  • Toriumi Kazuya
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
  • Horiuchi Yasue
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
  • Hatakeyama Sachiko
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
  • Uchida Miki
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
  • Inoue Tomoko
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science
  • Itokawa Masanari
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science

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Other Title
  • カルボニルストレス代謝障害と統合失調症
  • カルボニルストレス タイシャ ショウガイ ト トウゴウ シッチョウショウ

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Abstract

We previously reported that a certain subtype of schizophrenic patients exhibit idiopathic carbonyl stress with high plasma pentosidine levels and serum vitamin B6 depletion, which is referred to as carbonyl stress, without underlying diabetes or chronic kidney disease that are the two major cause of elevation of advanced glycation end products (AGEs) . Furthermore, we found the correlation between carbonyl stress and clinical features such as high ratio of inpatients, long duration of hospitalization, higher daily doses of anti - psychotics and lower educational status, suggesting that those patients might be treatment - registrant cases. We attempted to find associations between cognitive impairments and biochemical data. Schizophrenics were divided into four groups by their levels of pentosidine and vitamin B6, and we assessed the symptom severity by the Manchester Scale Japanese version, the cognitive function by Wechsler Adult Intelligence Scale 3rd version and Wisconsin card sorting test. We found that symptoms in high - risk group with high pentosidine and low vitamin B6 had a tendency to severe incoherence of thought and lower performance for digit span compared to that of other groups. Our preliminary data suggest that carbonyl stress might be associated with impaired working memory in schizophrenia. The comprehensive information covering in vitro and in vivo studies is important for evidence- based personalized for schizophrenic patients.

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