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- Numata Shusuke
- Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Kinoshita Makoto
- Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School
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- Ohmori Tetsuro
- Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School
Bibliographic Information
- Other Title
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- 統合失調症の DNA メチル化修飾異常
- トウゴウ シッチョウショウ ノ DNA メチルカ シュウショク イジョウ
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Abstract
DNA methylation is one of the major epigenetic mechanisms. We will introduce clinical DNA methylation studies of schizophrenia in this article. Attention to its role of DNA methylation in schizophrenia has recently increased because it has been shown that the environmental factors can influence the DNA methylation status, and the altered DNA methylation can affect gene expressions and behaviors. Like genetic studies, technological advances in DNA methylation enable us to perform genome - wide methylome analyses using a microarray and a next - generation sequencing. These epigenetic approaches will be useful to reveal novel molecular mechanisms of schizophrenia.
Journal
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- Japanese Journal of Biological Psychiatry
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Japanese Journal of Biological Psychiatry 26 (1), 7-14, 2015
Japanese Society of Biological Psychiatry
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Details 詳細情報について
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- CRID
- 1390001205412781952
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- NII Article ID
- 130005395582
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- NII Book ID
- AA12468060
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- ISSN
- 21866465
- 21866619
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- NDL BIB ID
- 026607790
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed