Neurophysiological profile of acoustic startle response : candidate endophenotype of Autism spectrum disorders

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  • Takahashi Hidetoshi
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan
  • Ishitobi Makoto
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Haraguchi Hideyuki
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Nonaka Shunsuke
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Asano Michiko
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan
  • Ohara Yuka
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Yamaguchi Honami
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Oshiyama Chiaki
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Ogino Kazuo
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Mochizuki Yukiko
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Miyake Atsuko
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry
  • Kamio Yoko
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry

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Other Title
  • 自閉症スペクトラム障害児における聴覚性驚愕反射の特性とエンドフェノタイプ候補可能性の検討
  • ジヘイショウ スペクトラム ショウガイジ ニ オケル チョウカクセイキョウガクハンシャ ノ トクセイ ト エンドフェノタイプ コウホ カノウセイ ノ ケントウ

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Abstract

The acoustic startle response (ASR) and its modulations are useful neurophysiological measurements in translational research. In particular, prepulse inhibition (PPI) of ASR is considered a candidate endophenotype of psychiatric diseases. However, findings from previous studies of PPI in autism spectrum disorders (ASD) have been inconsistent. Recently, we reported larger ASR magnitude to weak stimuli and prolonged peak startle latency in children with ASD. An atypical profile of ASR in ASD might therefore explain the inconsistent results in previous PPI studies. In addition, the relationship of ASR modulations to clinical characteristics of ASD is not known well. Thus, we investigated PPI with several prepulse intensities and its relationship to autistic traits and other emotional - behavioral problems in children with ASD and with typical development. Although, no significant difference for PPI or habituation was observed in ASD children compared to controls, habituation and PPI at relatively weak prepulse were negatively related to several autistic traits subscales and other emotional - behavioral problems, when considering all children. The comprehensive investigation of ASR and its modulation, including the magnitude of startle responses to weak stimuli peak startle latency, habituation, and PPI, might increase understanding of the neurophysiological impairments underlying ASD and other mental health problems in children.

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