Pathophysiology, Neurobiomarkers and Treatment in Three Subsets of Autism Spectrum Disorders

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  • Yui Kunio
    Department of Pediatrics, Dokkyo Medical University Research Institute of Pervasive developmental Disorders Research Institute of Pervasive Developmental Disorders, Ashiya University

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  • 自閉症スペクトラム障害の病態類型とバイオマーカー，治療方向性
  • ジヘイショウ スペクトラム ショウガイ ノ ビョウタイ ルイケイ ト バイオマーカー,チリョウ ホウコウセイ

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Abstract

Children with ASD and concomitant mitochondrial dysfunction have been reported to manifest clinical symptoms similar to those of mitochondrial disorders, and it therefore appears that the clinical manifestations of ASD with a concomitant diagnosis of mitochondrial dysfunction are likely due to these mitochondrial disorders. Disruption of ATP synthesis alone may be related to impaired glutathione synthesis. The adenosine triphosphate (ATP) production/oxygen consumption pathway may be a potential candidate for preventing mitochondrial dysfunction due to oxidative stress. A decrease in total antioxidant capacity may account for ASD children who show core social and behavioral impairments without neurological and somatic symptoms.

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