Development of image processing method for quantitative analysis of thrombus formation process in the microcirculation

DOI
  • Zheng Xiao-xiang
    Department of Opitical and Scientific Instrumentation, Institute of Biomedical Engineering, Zhejiang University
  • Ning Gang-ming
    Department of Opitical and Scientific Instrumentation, Institute of Biomedical Engineering, Zhejiang University
  • Lin Wen
    Department of Opitical and Scientific Instrumentation, Institute of Biomedical Engineering, Zhejiang University
  • Ohshima Norio
    Department of Biomedical Engineering, Institute of Basic Medical Sciences, University of Tsukuba

Bibliographic Information

Other Title
  • 画像処理を利用する微小血管内血栓形成過程の定量的解析法

Abstract

Using a intravascular thrombus formation model produced by irradiation of the filtered light and intravascualr administration of fluorescein sodium, we developed an image processing technique to study the dynamic process of thrombus formation in vivo. Recorded video images were converted into the digital images and analyzed by an IBM PC/386 personal computer. To improve the quality of digitized images we utilized the digital filtering and smoothing method. We then used segmental analysis method and differential histogram to distinguish the regions of the blood flow and the thrombus. The image processing technique thus developed enabled measurement of time course changes of thrombus size. In animal experiments we found the thrombus growth and separation were balanced during the procedure of thrombus formation. This method is useful for studying mechanism of thrombus growth and evaluating the pharmacological effects of anti-platelet aggregating drugs.

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Keywords

Details 詳細情報について

  • CRID
    1390001205421089536
  • NII Article ID
    130001933540
  • DOI
    10.11262/jpnbr1987.7.2_26
  • ISSN
    09134778
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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