Predictable nucleated cell count of harvested bone marrow using platelet count in unrelated donors

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  • Okada Yosuke
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Yamamura Takeshi
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Teramoto Masahiro
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Tachi Noriaki
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Kawamura Toshikuni
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Horiuchi Toshikatsu
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Kato Shoichiro
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Saga Reina
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Maekawa Takaaki
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Watanabe Junichi
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Kobayashi Ayako
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Osawa Yukiko
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Kobayashi Shinichi
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Sato Ken
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital
  • Kimura Fumihiko
    Division of Hematology, Department of Internal Medicine, National Defense Medical College Hospital

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  • 血小板数を用いた非血縁ドナーから採取される有核細胞数の予測

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<p> We analyzed the relationship between unrelated donor characteristics (age, sex, height, body weight, and complete blood count) and nucleated cell count concentration in harvested bone marrow between August 2007 and November 2015 at our hospital. All 57 donors met the bone marrow harvesting criteria of Japan Marrow Donor Program. A stepwise multiple regression analysis indicated a significant correlation between the platelet count and the concentration of nucleated cells. Using the derived predictive formula, we illustrated bone marrow volume depending on the platelet count to obtain 2.3×108 nucleated cell count per patient’s body weight. In bone marrow transplantation for patients weighing<60 kg, it is possible to obtain adequate nucleated cell count by increasing their self-blood, even if their platelet counts are relatively low. In contrast, the maximum volume of self-blood may not make it possible to achieve required nucleated cell count for the patients weighing>70 kg. It may be a useful strategy that we select donors with high level of platelet count or who can provide their peripheral blood stem cell.</p>

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