Effect of hypocapnia on microcirculation

Nakata Tomoko, Takada Katsumi, Komori Makiko, Suzuki Hidehiro, 菅原 基晃

doi:10.11262/jpnbr1987.11.3_27

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Other Title

動脈血二酸化炭素分圧低下時の微小循環動態
動脈血二酸化炭素分圧低下時の微小循環動態--Rabbit Ear Chamber法を用いて
ドウミャクケツ 2サンカタンソブンアツテイカジノビショウジュンカン
using rabbit ear chamber method
Rabbit Ear Chamber法を用いて

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Using the rabbit ear chamber (REC) method, the author compared the effect of hypocapnia and that of normocapnia on cutaneous microcirculation of rabbits. Eight rabbits, weighting 3-4kg, were used for this study, which were anesthetized with pentobarbital and pancuronium. To maintain PaO₂ at 100-150mmHg and PaCO₂ at 20-25mmHg (HYPOCAPNIC GROUP), they were mechanically ventilated with air-O₂ and regulated. After observing the circulation of arteriole during hypocapnia for 15-20 minutes, to induce normocapnia, 100% CO₂ was added to the inspired gas stepwise until PaCO₂ reached 35-45mmHg (NORMOCAPNIC GROUP). And the circulationof arteriole was observed during normocapnia for 15-20 minutes.<BR>No significant changes were observed in the blood pressure, heart rate and pulse pressure. However, significant change was observed in pH. During hypocapnia, the diameter, blood-flow velocity and blood-flow rate of the arterioles were markedly reduced (p<0.05).<BR>This study using REC has shown that hypocapnia causes cutaneous microcirculatory changes and increase systemic vascular resistance.

Journal

Journal of Japanese Society of Biorheology

Journal of Japanese Society of Biorheology 11 (3), 27-33, 1997

JAPANESE SOCIETY OF BIORHEOLOGY

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