Modelling of aggregation in aneurysm

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  • SHIMANO Kenjiro
    Department of Mechanical Systems Engineering Musashi Institute of Technology
  • Hayashi Toshihiro
    Department of Mechanical Systems Engineering Musashi Institute of Technology
  • UJIIE Hiroshi
    Department of Neurosurgery, Tokyo Women's Medical University
  • ONO Takashi
    Department of Mechanical Systems Engineering Musashi Institute of Technology
  • ENOMOTO Yoshiteru
    Department of Mechanical Systems Engineering Musashi Institute of Technology

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Other Title
  • 脳動脈瘤内における凝集のモデリング
  • ノウ ドウミャクリュウナイ ニ オケル ギョウシュウ ノ モデリング

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Description

Thrombi are often observed in aneurysms and are considered to play an important role in rupture. It is crucial to scrutinise any correlation between the probability of rupture and the extent of thrombus generation. Numerical techniques such as CFD seem promising for this purpose. However, there are, at present, no models that allow us to evaluate thrombus generation. The authors aim at the proposal of such a model. In the present paper, the process of platelet aggregation is discussed. In blood flow near the entry to an aneurysm, red blood cells are haemolysed due to high pressure. Adenosine diphosphate (ADP) in those haemolysed red blood cells is released into the plasma and induces the aggregation. Making reference to actual aggregation curves of human plasma for various ADP concentrations, the authors modelled the rate at which the density of aggregated platelets continues to increase. Furthermore, the present model was applied to blood flow in an endothelialised glass aneurysm in combination with CFD. As a result, the distribution of platelets clotting in an aneurysm was obtained.

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