- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Automatic Translation feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Compliance and Clinical Efficacy of Pilocalpine Hydrochrolide (Salagen<sup>®</sup>) for Sjögren Syndrome Patients by the Gradually-increasing Administration
-
- TASHIMA Rie
- Department of Dentistry and Oral-Maxillo-Facial Surgery, Oita University
-
- TAKAHASHI Yoshihiro
- Department of Dentistry and Oral-Maxillo-Facial Surgery, Oita University
-
- KAWANO Kenji
- Department of Dentistry and Oral-Maxillo-Facial Surgery, Oita University
Bibliographic Information
- Other Title
-
- シェーグレン症候群患者に対するピロカルピン塩酸塩（サラジェン錠<sup>®</sup>）漸増投与法のコンプライアンスと臨床効果の検討
- Compliance and Clinical Efficacy of Pilocalpine Hydrochrolide (Salagen^|^reg;) for Sj^|^ouml;gren Syndrome Patients by the Gradually-increasing Administration
Search this article
Description
Pilocarpine hydrochloride (Salagen®) is currently indicated for the treatment of xerostomia caused by Sjögren syndrome (SS). However, administration of this drug is frequently discontinued because of adverse effects. In this study, we examined the compliance and clinical efficacy of the gradually-increasing administration of pilocarpine. Twenty-six SS patients (2 men, 25 women, mean age 64 years, range 40-85) received 7.5mg pilocarpine per day for the first 4 weeks, and then 15mg pilocarpine per day for further 8 weeks. Nineteen patients (73.1%) completed administration for total 12 weeks, and 7 patients failed it (3 patients stopped administration until the 4th week, and 4 patients after the 4th week). When calculated with 23 patients whose daily dose increased to 15mg, the completion rate was 82.6%. Saxon test and questionnaires revealed an increase in saliva-flow rate in 88.9% of 19 patients and improvements of subjective and objective symptoms in over 50%. The results suggested that 15mg of pilocarpine was well tolerated in patients who underwent the gradually-increasing administration.
Journal
-
- Journal of Japanese Society of Oral Medicine
-
Journal of Japanese Society of Oral Medicine 19 (1), 1-7, 2013
Japanese Society of Oral Medicine
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001205423451520
-
- NII Article ID
- 130004624656
-
- ISSN
- 21866155
- 21866147
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed
