Retrospective Study on Clinical Efficacy of Cepharanthine for Oral Lichen Planus as Determined by the Multiple Institutes Collaborative Project

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  • SUGAWARA Yumiko
    Division of Oral Diagnosis, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry
  • JINBU Yoshinori
    Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University
  • SASANO Takashi
    Division of Oral Diagnosis, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry
  • KUSAMA Mikio
    Department of Dentistry, Oral and Maxillofacial Surgery, International University of Health and Welfare
  • MORI Yoshiyuki
    Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University
  • KITAGAWA Yoshimasa
    Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University
  • TAKAHASHI Tetsu
    Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry
  • SUGIYAMA Yoshiki
    Divison of Oral Maxillofacial Surgery, Department of Reconstructive Oral and Maxillofacial Surgery, Iwate Medical University
  • FUKUDA Masayuki
    Department of Dentistry and Oral Surgery, Akita University Graduate School of Medicine
  • KAWAMATA Hitoshi
    Department of Oral and Maxillofacial Surgery, Dokkyo Medical University School of Medicine
  • SHIBATA Toshiyuki
    Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine
  • UENO Takaaki
    Department of Dentistry and Oral Surgery, Osaka Medical College
  • KISHIMOTO Hiromitsu
    Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine
  • IIDA Seiji
    Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • NAKAMURA Norifumi
    Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Kagoshima University Graduate School of Medical and Dental Sciences
  • SUGIURA Tsuyoshi
    Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Kagoshima University Graduate School of Medical and Dental Sciences

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Other Title
  • 口腔扁平苔癬に対するCepharanthineの臨床効果に関する後方視的多施設共同研究
  • コウコウ ヘンペイ タイセン ニ タイスル Cepharanthine ノ リンショウ コウカ ニ カンスル コウホウ シテキ タシセツ キョウドウ ケンキュウ

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Abstract

Retrospective study on clinical efficacy and safety of the Cepharanthin long-term use for the patient with oral lichen planus （OLP） was performed at 12 institutes as a multiple institution collaborative project. We examined the degree of the severity of the disease, improvement rate and the side effects of the Cepharanthin use at 4 weeks and 6 months after the prescription and at the endpoint of the Cepharanthin use for eighty OLP patients given the Cepharanthin for more than 4 weeks within a period from July 2008 to June 2013.<br>More than 50％ improvement rate was observed in almost all clinical types of OLP and the location of the lesions following to the Cepharanthin use. The improvement rate showed higher value at the endpoint of the Cepharanthin prescription, and long-term use revealed much higher efficacy for improving OLP. On the other hand, the dosage of the Cepharanthin showed no significant different effect for the OLP improvement. In addition, we recognized high improvement rate of the Cepharanthin use even in the case without steroid use. As a result, eighty percent of the OLP cases showed significant improvement by means of the Cepharanthin use, in addition, there was no significant adverse events following to the Cepharanthin use. From the above results, it can be concluded that the Cepharanthin has a significant efficacy for the treatment of OLP.

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