膵・消化管神経内分泌腫瘍の疫学の動向

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  • Trends of epidemiology of pancreatic and gastrointestinal neuroendocrine tumors in Japan
  • スイ ・ ショウカカン シンケイ ナイブンピ シュヨウ ノ エキガク ノ ドウコウ

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There have been few epidemiological data on gastroenteropancreatic neuroendocrine tumors (GEPNETs) in Japan. First, we reported the epidemiology of pancreatic endocrine tumors (PNETs) and gastrointestinal neuroendocrine tumors (GI-NETs) in Japan in 2005. Next, we conducted the second survey regarding with GEPNETs patients who received treatment in 2010. A total of 3,379 individuals received treatment for PNETs in 2010. The number of patients in 2010 was an increase of about 1.2 times as compared to that in 2005. Non-functioning tumor (NF)-PNET constituted 64.5％, followed by insulinoma (20.9％) and gastrinoma (8.2％). On the other hand, an estimated 8,088 patients received treatment for GI-NETs. The number of patients in 2010 was an increase of about 1.8 times as compared to that in 2005. The locations of GI-NETs varied: foregut, 26.1％; midgut, 3.6％; and hindgut, 70.3％. The frequency of carcinoid syndrome in GI-NETs was only 3.2％. The results show that the number of Japanese patients with GEP-NET in 2010 was an increase compared in 2005.

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