Septic shock and acute respiratory distress syndrome in Ph-positive acute lymphoblastic leukemia treated with imatinib-containing chemotherapy: A case report
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- Iwamoto Mayumi
- Department of Pediatrics, Ehime Prefectural Central Hospital
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- Tezuka Mari
- Department of Pediatrics, Ehime Prefectural Central Hospital
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- Sugita Atsuro
- Department of Pathology, Ehime Prefectural Central Hospital
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- Kawakami Sanae
- Department of Pediatrics, Matsuyama Red Cross Hospital
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- Miyawaki Reiji
- Department of Pediatrics, Matsuyama Red Cross Hospital
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- Yonezawa Sachiko
- Department of Pediatrics, Matsuyama Red Cross Hospital Department of Pediatrics, Ehime University Graduate School of Medicine
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- Jogamoto Toshihiro
- Department of Pediatrics, Ehime Prefectural Central Hospital
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- Kuwabara Kozue
- Department of Pediatrics, Ehime Prefectural Central Hospital
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- Koizumi Munemitsu
- Department of Pediatrics, Ehime Prefectural Central Hospital
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- Nakano Takeshi
- Department of Pediatrics, Ehime Prefectural Central Hospital
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- Yamamoto Eiichi
- Department of Pediatrics, Ehime Prefectural Central Hospital
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- Ishii Eiichi
- Department of Pediatrics, Ehime University Graduate School of Medicine
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- Ishida Yasushi
- Department of Pediatrics, Ehime Prefectural Central Hospital
Bibliographic Information
- Other Title
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- Imatinib併用化学療法治療中に敗血症性ショックと急性呼吸窮迫症候群を合併したフィラデルフィア染色体陽性急性リンパ性白血病の1例
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Abstract
<p>Despite the improved outcome of Ph-positive acute lymphoblastic leukemia (Ph+ ALL) with tyrosine kinase inhibitors in children, side effects and complications of treatment are still major concerns. In this report, we describe the case of a 13-year-old boy who was diagnosed as having Ph+ ALL and treated with chemotherapy including imatinib. He developed febrile neutropenia on day 14 after the re-induction therapy. An antibiotic agent was immediately administered to the patient, but septic shock and, following acute renal failure, intestinal edema and acute respiratory distress syndrome progressed. He died on day 62. Autopsy findings showed that the cause of death was multiple organ failure from septic shock. E. coli was detected in his blood culture. The mechanism of sepsis was considered as a bacterial translocation from his intestine. These findings show that the immediate use of antibiotics in the case of prolonged febrile neutropenia is recommended, because bacterial translocation will be induced by the imatinib-containing chemotherapy in Ph+ ALL patients.</p>
Journal
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- The Japanese Journal of Pediatric Hematology / Oncology
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The Japanese Journal of Pediatric Hematology / Oncology 54 (1), 15-20, 2017
The Japanese Society of Pediatric Hematology / Oncology
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Keywords
Details 詳細情報について
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- CRID
- 1390001205425612928
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- NII Article ID
- 130005681214
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- ISSN
- 21895384
- 2187011X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed