Methotrexate-induced bullous acral erythema in a 2-year-old girl with acute lymphoblastic leukemia

DOI

Bibliographic Information

Other Title
  • Methotrexateによりbullous acral erythemaを発症した急性リンパ性白血病の2歳女児例

Description

<p>Acral erythema (AE), also known as palmar-plantar erythrodysesthesia syndrome, is a painful and edematous reddening of the palms and soles, which often emerges as an adverse effect of high-dose chemotherapy. A 2-year-old girl exhibited multiple bullous and erythematous lesions with pain and numbness in her palms and soles after high-dose methotrexate (MTX) treatment for acute lymphoblastic leukemia. The same lesions reemerged by repeating either high- or intermediate-dose MTX therapy. Direct deposition of MTX in the eccrine gland and its cytotoxic effects were considered as the mechanisms of AE pathogenesis since the severity of AE correlated with the MTX dose. However, allergic reactions may also contribute to the pathogenesis because the lymphocyte stimulation test showed a positive reaction to MTX. The lesions were successfully treated with topical and systemic corticosteroid therapy. Chemotherapy-induced AE does not affect the prognosis of the underlying disease; therefore, it is not necessary to alter the subsequent chemotherapy.</p>

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Details 詳細情報について

  • CRID
    1390001205426436096
  • NII Article ID
    130005606054
  • DOI
    10.11412/jspho.53.309
  • ISSN
    21895384
    2187011X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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