Gene admixture in the Silk Road region of China: Evidence from mtDNA and melanocortin 1 receptor polymorphism.

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  • Yao Yong-Gang
    Laboratory of Cellular and Molecular Evolution, Kunming Institute of zoology, the Chinese Academy of Sciences
  • Lü Xue-Mei
    Laboratory of Cellular and Molecular Evolution, Kunming Institute of zoology, the Chinese Academy of Sciences
  • Luo Huai-Rong
    Laboratory of Cellular and Molecular Evolution, Kunming Institute of zoology, the Chinese Academy of Sciences
  • Li Wen-Hsiung
    Department of Ecology and Evolution, University of Chicago
  • Zhang Ya-Ping
    Laboratory of Cellular and Molecular Evolution, Kunming Institute of zoology, the Chinese Academy of Sciences

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Mitochondrial DNA control region segment I sequences and melanocortin 1 receptor (MC1R) gene polymorphism were examined in ethnic populations in the silk road region of China. Both the frequencies of the MC1R variants and the results of mtDNA data in this region presented intermediate values between those of Europe and East and Southeast Asia, which suggested extensive gene admixture in this area and was in general agreement with previous studies. Phylogenetic analysis of the ethnic populations in the Silk Road region that based on mtDNA data didn't show expected cluster pattern according to their ethnogenesis. We suspect that a high migration rate in female among these closely related populations and other three demographic events might account for it.<br>

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