Compensatory changes in silver-stainability of nucleolar organizer regions in mice.
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- SUZUKI Hitoshi
- Division of Molecular Genetics, Institute of Medical Science, Jikei University School of Medicine
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- SAKURAI Susumu
- Division of Molecular Genetics, Institute of Medical Science, Jikei University School of Medicine
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- NISNIMURA Masahiko
- Institute of Experimental Animals, Hamamatsu University School of Medicine
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- KOMINAMI Ryo
- Department of Biochemistry, Faculty of Medicine, Niigata University
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- MORIWAKI Kazuo
- Department of Cell Genetics, National Institute of Genetics
Bibliographic Information
- Other Title
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- マウス仁形成体部位の銀染色性の補償的変化〔英文〕
- マウス ジン ケイセイタイ ブイ ノ ギン センショクセイ ノ ホショウテキ
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Description
Silver-stainability of nucleolar organizer regions (NORs) that contain genes for ribosomal RNA (rDNA) was investigated using two mouse strains, BALB/cCrSlc and MOA, and their hybrid progeny. The patterns of segregation of the rDNA clusters were analyzed in terms of chromosomal C-banding and by use of a polymorphic probe for the variable region in backcrossed N2 and N3 individuals. The results indicate that the intensity of Ag-NOR staining is stably inherited in most of the rDNA clusters, irrespective of different genetic backgrounds. In some clusters, such as those on chromosome 12 of BALB/cCrSlc, a modulation of the intensity is observed. This modulation seems to be due to compensatory activation via a change in the number of actively transcribed genes. The change from silver-negative to silver-positive staining of the NOR of chromosome 12 of BALB/cCrSlc was correlated with demethylation of the genes.<br>
Journal
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- The Japanese Journal of Genetics
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The Japanese Journal of Genetics 67 (3), 217-232, 1992
The Genetics Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001205445274624
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- NII Article ID
- 10006699251
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- NII Book ID
- AA00690924
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- ISSN
- 18805787
- 0021504X
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- NDL BIB ID
- 3786337
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- PubMed
- 1445722
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed