Linkage of the Dao-1 gene for D-amino-acid oxidase to the pgm-1 gene for phosphoglucomutase-1 on the mouse chromosome 5.

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  • KONNO Ryuichi
    Department of Microbiology, Dokkyo University School of Medicine
  • NIWA Akira
    Department of Microbiology, Dokkyo University School of Medicine
  • YASUMURA Yosihiro
    Department of Microbiology, Dokkyo University School of Medicine

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Other Title
  • D-アミノ酸酸化酵素遺伝子(Dao-1)とマウス第5染色体のホスホグルコムターゼ遺伝子(Pgm-1)との連鎖
  • D-アミノ酸酸化酵素遺伝子(Dao-1)とマウス第5染色体のホスホグルコムターゼ遺伝子(Pgm-1)との連鎖〔英文〕
  • D アミノサン サンカ コウソ イデンシ Dao-1 ト マウス ダイ 5 セ

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Linkage of the Dao-1 gene controlling D-amino-acid oxidase to the Pgm-1 gene controlling phosphoglucomutase-1 on the mouse chromosome 5 was examined. Mutant ddY/DAO- mice carrying a null Dao-1c allele had a Pgm-1a allele. Mutant mice were crossed to C3H/HeN and NZB/Kl mice carrying the Dao-1+ and Pgm-1b alleles. The hybrid F1 mice were backcrossed to the ddY/DAO- and their progeny were examined for alleles for D-amino-acid oxidase and phosphoglucomutase-1. In both backcrosses, the progeny with recombinant-type combinations of the alleles were significantly less than the progeny with the parental-type combinations, indicating the linkage of the Dao-1 and Pgm-1 genes. The recombination frequency between these loci was estimated to be 19.8±4.0%.

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