姉妹染色分体交換とDNAヌクレオチド合成経路の代謝撹乱との関係
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- SUZUKI Hitoshi
- National Institute of Genetics
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- YOSIDA Tosihide H.
- National Institute of Genetics
書誌事項
- タイトル別名
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- Relation between the sister chromatid exchanges and metabolic perturbation of deoxyribonucleotide synthesis.
- 姉妹染色分体交換とDNAヌクレオチド合成経路の代謝撹乱との関係〔英文〕
- シマイ センショク ブンタイ コウカン ト DNA ヌクレオチド ゴウセイ ケ
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説明
The sister chromatid exchange (SCE) in Chinese hamster D-6 cells was induced by treatment with the excess amounts of deoxyribonucleosides such as dA, dG, and dT or their mixtures. The induction of the SCE, however, was suppressed by additions of dC and combinations of the other deoxyribonucleosides with dC. These results suggested that SCEs could be induced by the inhibition of ribonucleotide reductase activity, namely, metabolic perturbation of deoxyribonucleotide synthesis. On the other hand, SCE was induced by hydroxyurea (HU) at about two times of control. SCE inducing by HU, however, was not suppressed by simultaneous addition of deoxyribonucleosides (dA, dG, dT, and dC). This result means that induction of SCE by HU was not due to the depletion of deoxyribonucleotides, but it might be due to any other factor which is unknown at present.
収録刊行物
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- 遺伝学雑誌
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遺伝学雑誌 58 (4), 369-372, 1983
日本遺伝学会
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詳細情報 詳細情報について
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- CRID
- 1390001205446062848
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- NII論文ID
- 130000060382
- 220000026391
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- NII書誌ID
- AA00690924
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- ISSN
- 18805787
- 0021504X
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- NDL書誌ID
- 2600146
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可