Gonado-somatic Index, Plasma Vitellogenin and Thyroxine Levels and Hepatic Microsomal Cytochrome P-450 Content of Carp, <I>Cyprinus carpio</I>, from the Tama and the Kitakami Rivers

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  • KAKUTA Izuru
    Department of Biotechnology, Senshu University of Ishinomaki

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Other Title
  • 多摩川と北上川に生息するコイの生殖腺指数, 血漿中ビテロゲニンとチロキシン濃度, および肝ミクロソーム内チトクロムP-450含量
  • 多摩川と北上川に生息するコイの生殖腺指数,血漿中ビテロゲニンとチロキシン濃度,および肝ミクロソーム内チトクロムP-450含量:内分泌攪乱化学物質汚染の実態調査
  • タマガワ ト キタカミガワ ニ セイソク スル コイ ノ セイショクセン シスウ ケッショウ チュウ ビテロゲニン ト チロキシン ノウド オヨビ キモ ミクロソーム ナイ チト クロム P 450ガンリョウ ナイブンピ カクラン カガク ブッシツ オセン ノ ジッタイ チョウサ
  • Research for Actual Effects of Endocrine Disrupting Chemicals
  • 内分泌攪乱化学物質汚染の実態調査

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Abstract

In order to understand the actual effect of endocrine disrupting chemicals on aquatic animals inhabiting the Tama and the Kitakami Rivers as well as the potential health and ecological effects of such chemicals on river wildlife species, the gonado-somatic index (GSI), gonado morphology, plasma vitellogenin (VTG) and thyroxine (T4) levels, and hepatic microsomal Cytochrome P-450 (Cyt. P-450) content of carp, Cyprinus carpio, caught at lower parts of the rivers were studied in May and November, 1998. No abnormality was observde in the ovaries of female carp from both rivers or in the testes of male fish from the Kitakami River in May. There was no significant difference in plasma VTG levels from female carp collected at the Tama and those collected at the Kitakami in May and November. On the other hand, some male fish from the Tama River displayed testicular abnormalities (about25%) and higher levels of plasma VTG (approximately50%) than those from the Kitakami River in May. Significant negative relationship between GSI and plasma VTG levels was also indicated in male fish from the Tama River at that time. Furthermore, in November high plasma VTG was found in male carp from the Tama River.<BR>No significant difference in plasma T4 and hepatic Cyt. P-450 content from carp collected at both rive was recorded. A positive relationship between hapatic Cyt. P-450 content and plasma VTG level was found in male carp from the Tama River in May. In November, a significant negative relationship between hepatic Cyt. P-450 content and plasma T4 level was detected in female carp from the Kitakami River and in male fish from both rivers. A significant relationship between plasma T4 and VTG levels was not indicated in female or male carp from either river.<BR>On the basis of these findings,(i) it is concluded that the reproductive health and maybe other physiological functions of male carp inhabiting the Tama River which runs through the Tokyo metropolitan area are perhaps being influenced by exposure to oestrogenic substances, while the effects on female carp are not clear, and (ii) it suggested that female and male carp inhabiting the Kitakami River are also incurring endocrine dysfunctions by means of chemical contaminants, though the extent is not so severe as that in the Tama River.

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