実験扁平上皮癌に対するレーザー光と超音波の併用照射による治療効果の検討
書誌事項
- タイトル別名
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- Combined Effects of Photodynamic and Sonodynamic Treatment on Experimental Skin Cancer on C3H Mice
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説明
A new therapeutic modality for cutaneous malignancies, ultrasonic irradiation of tumors administrated with sensitizers, is known as sonodynamic therapy (SDT). In previous references, a few photosensitizers (such as hematoporphyrin, Photofrin-II [Pf-11], and gallium-porphyrin analogue ATX-70) have been reported to have sonodynamically cytotoxic effects. In recent years, many photosensitizers have been developed, for example, ATX-70, a pheoforbide derivative (PH-1126), hematoporphyrin oligomer (HpO), 5-aminolevulinic acid (5-ALA), Photofrin-II and aluminum phthalocyanine tetrasulphonate (AlPcS4). The antitumor effects of PDT or SDT with the sensitizers were determined and compared in C3H mice bearing transplanted squamous cell carcinoma (SCC). In order to enhance the efficiency, the combination of PDT and SDT with PH-1126 or ATX-70 were compared with that of PDT or SDT alone. From the results, the combined antitumor effect of PDT and SDT was stronger than that of single PDT or SDT. In conclusion, it was suggested that combined treatment (PDT+SDT) developed the efficiencies of these single treatments.
収録刊行物
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- The Journal of Japan Society for Laser Surgery and Medicine
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The Journal of Japan Society for Laser Surgery and Medicine 18 (Supplement), 157-160, 1997
Japan Society for Laser Surgery and Medicine
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詳細情報 詳細情報について
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- CRID
- 1390001205456246016
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- NII論文ID
- 130004630573
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- ISSN
- 02886200
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可