Dysfunction and Restoration of Damaged Salivary Glands

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  • MISHIMA Kenji
    Division of Pathology, Department of Oral Diagnostic Sciences, Showa University School of Dentistry

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  • 唾液腺の機能障害とその回復
  • ダエキセン ノ キノウ ショウガイ ト ソノ カイフク

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Abstract

Dry mouth promotes dental caries, disorders of eating and swallowing, and aspiration pneumonia, which result in remarkable decrease of quality of life (QOL) in severe cases. Cell transfer therapy using stem cells is a promising treatment for the patients suffering from severe dry mouth due to the ability of reconstituting damaged glands. Stem cells are classified into three groups: tissue stem cells, embryonic stem cells (ES cells), and induced pluripotent stem cells (iPS cells). To date, it is reported that salivary stem cells can recover the hypofunction of salivary glands, which is mediated through not only reconstituting the glands but also soluble factors in a paracrine manner. We have focused on a cell population called “side population (SP)” cells, which can be isolated without using a cell surface marker. Since their first isolation from bone marrow as a fraction containing a high frequency of stem cells, SP cells have been analyzed in a variety of organs. In the present study, we investigated the effects of experimental treatment with SP cells using a mouse model of irradiationinduced salivary gland dysfunction, and the possibility of establishing a treatment approach with a specific factor expressed in SP cells.

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