Inhibitory Effect of Indole on the Esophageal and Vesical Tumors Induced by Dibutylnitrosamine in Rats

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  • Inhibitory Effect of Indole on the Esop

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Influence of the dietary Indole upon the tumorigenesis with DBN was investigated in Wistar male rats. DBN was either suspended (0.05w/v%) in the drinking water or dissolved (2w/v%) in sesame oil. Indole was supplemented (1.6%) with the basal diet. Both Group 1 fed on the basal diet and Group 2 fed on the basal diet supplemented with Indole were given freely the drinking water containing DBN. Both Group 3 fed on the basal diet and Group 4 fed on the basal diet supplemented with Indole were injected subcutaneously by DBN,50 mg/kg, twice a week for 24 weeks. Experimental rats were given the special water or the special diet in the time between 6-28 weeks of age. They were sacrificed in the age of 28-40 weeks.<BR>The incidence of esophageal tumors was 100% in Group 1,70% in Group 2,60% in Group 3, and 5% in Group 4, respectively. While that of vesical tumors was 50% in Group 1,20% in Group 2,73% in Group 3, and 30% in Group 4, respectively. As the hepatic tumors had developed in all experimentally effective rats for DBN-tumorigenesis, there was no difference from each other group. Both higher incidence of esophageal tumors in the rats drunk with DBN and lower incidence of esophageal tumors in rats injected by DBN would indicate the direct action of DBN on the esophageal mucosa. Dietary Indole inhibited prominently, the tumorigenesis with DBN in male rats. Therefore, a competition between DBN and Indole might be speculated in the tumorigenesis of the target tissues.

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