抗不整脈薬の研究

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タイトル別名
  • Studies of Antiarrhythmics, Especially Effects of Quinidine, Lidocaine, Propranolol and Carteolol on Cardiac Muscle Contractility
  • 抗不整脈薬の研究--特に心筋の収縮性に対するQuinidine,Lidocaine,Propranolol,Carteololの作用について
  • コウ フセイミャクヤク ノ ケンキュウ トクニ シンキン ノ シュウシュクセイ
  • 特に心筋の収縮性に対するQumidine, Lidocaine, Propranolol, Carteololの作用について

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The contractility of the spontaneously contracting atrium as well as the electrically driven left atrium and papillary muscle isolated from rat heart was tested in Locke's solution saturated with pure oxygen at 25,30,35,40°C, and the action of quinidine, lidocaine, propranolol and carteolol in the medium at 30°C was comparatively studied.<BR>1. When the temperature of medium was increased, the beat rate of spontaneously contracting atrium was increased but its maximum developed tension was decreased; and in electrically driven left atrium and papillary muscle, the maximum developed tension was decreased, the contraction and relaxation velocities were increased, the refractory period was decreased, and the maximum driven frequency was increased with increasing the temperature: the change of contraction and relaxation velocities in left atrium was more than those of papillary muscle.<BR>2. The maximum driven frequency of cardiac muscle was dependent on the time from the end of ralaxation to contraction initiation of the muscle (the recovery time of muscle contraction). Propranolol increased the time in papillary muscle, carteolol increased that in left atrium.<BR>3. Propranolol, lidocaine and quinidine suppressed the beat rate of atrium as well as maximum developed tension of left atrium and papillary muscle, while carteolol did not.<BR>4. The refractory period of the atrium was increased by quinidine, lidocaine and carteolol, while that of papillary muscle was increased by propranolol.<BR>5. The recovery time of muscle contraction in left atrium was increased by carteolol while that in papillary muscle was increased by propranolol and lidocaine. The time of each muscle was increased by quinidine.<BR>6. Lidocaine is characteristic in the increase of the recovery time rather than in the increase of the refractory period in papillary muscle, and quinidine is so in the increase of the refractory period rather than in the increase of the recovery time in left atrium.<BR>7. From the results, it was assumed that quinidine acts easily on atrial muscle while lidocaine and propranolol on papillary muscle to increase the refractory period and the recovery time of muscle, and that carteolol prolongs the recovery time of the atrial muscle contraction.

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