Perphenazineによる精神分裂病治療時の経時的脳波変動

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タイトル別名
  • Electroencephalographic Changes in the Course of Perphenazine Treatment of Schizophrenia
  • Perphenazineによる精神分裂病治療時の経時的脳波変動--電算機による精密解析
  • Perphenazine ニヨル セイシン ブンレツビョウ チリョウジ ノ ケ
  • Minute Analysis Using Comquter
  • 電算機による精密解析

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It is widely known that abnormality of basic activities in EEG appear and increase in the schizophrenic patients during psychotropic drug treatment. There are several communications with regard to this phenomenon and the authors seem to intend for groping some way to physiological aspect of the recovery process and for finding a new clue to develope ant i-psychot ic substances.<BR>The research group to which the present author belongs has been studying on computerized analysis of EEG changes in psychotic patients as well as neurotic and epileptic ones during drug treatment since 1970 by using various analytic methods. In this communication, the author presents the results of CEEG (Itil) study on influences of perphenazine treatment and of its outcome to brain function in 12 patients with schizophrenia, seven hebephrenic and five paranoid types, who were deprived from any medical care at least for one month. Their pre-treatment EEG showed no particular abnormalities in visual evaluation. Clinical observations have been made by the author and important symptoms were regularly evaluated with Expanded form of B. P. R. S. The dosage was fixed at eight miligrams per os three times daily throughout the study.<BR>EEG changes induced by perphenazine are not so uniform in schizophrenic patients as seen in nomal volunteers; the change of major tranquilizer (Itil) were seen in the majority of 12 patients after one month of the treatment, while it was different in case by case at three hours after a single dose administration. In particular, the patient who showed little or no improvement, who was diagnosed as hebephrenic type, who showed very low incidence of alpha activity, who was in his twenties, and Who did not develope any sign of extrapyramidal symptom, presented a similar changes to the major tranquilizer type in normal subjects. In the contrary, one who showed a clinical improvement, who was diagnosed as paranoid type, whose history was relatively short, who was in his thirties, who showed ahigh incidence of alpha activity, who pre sented extrapyramidal side effects, showeb a transient increase of fast activities, at the beginning of perphenazine treatment, and then the EEG change gradually shifted to present the major tranquilizer type. Therefore, it may be concluded that the EEG changes at the beginning of perphenazine treatment can be a predicter of clinical outcome of patient with schizophrenia.

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