Arginine Imbalanced Dietによる発癌抑制に関する実験的研究

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タイトル別名
  • Inhibitory Effect of Agrinine-Supplemented Diets upon Mammary Carcinogenesis
  • Arginine Imbalanced Dietによる発癌抑制に関する実験的研究-2-Arginine Imbalanced DietによるWalker 256 Carcinosarcomaの発育抑制に関する実験的検討
  • Arginine Imbalanced Diet ニヨル ハツガン ヨクセイ
  • Part 2 Effects of Arginine-Supplemented Diets on Growth of Walker 256 Carcinosarcoma
  • 第2編Arginine Imbalanced DietによるWalker256Carcinosarcomaの発育抑制に関する実験的検討

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The experiments described in Part 1 showed that the growth of tumors induced by 7,12-DMBA was decreased in rats fed arginine-supplemented diets.<BR>This paper described the effect of arginine-supplemented diets on the growth of Walker 256 carcinosarcoma.<BR>In the first experiment, female Wistar rats were fed on three different synthetic diets;<BR>1) 20% casein (control)<BR>2) 15% casein supplemented with 5 % arginine<BR>3) 12% casein supplemented with 8 % arginine<BR>Three million cells of Walker 256 carcinosarcoma were inoculated subcutaneously. The experimental diets were given for 10 days after inoculation. All animals had free access to water. The average body weight gains did not differ much from each other in the three groups, but significantly lower tumor weights were observed in the arginine-supplemented diet groups.<BR>In the second experiment, the diets were started 15 days before and continued for 10 days after inoculation.<BR>The effect of the arginine-supplemented diets on tumor growth was even greater than in the first experiment.<BR>In attempt to clarified the mechanism of inhibition of tumor growth by arginine supplementation, the urea content of Walker 256 carcinosarcoma was examined.<BR>An increased urea concentration was found in tumor tissues of rats fed argininesupplemented diets.<BR>Local injections of various concentrations of urea definitely inhibited the growth of Walker 256 carcinosarcoma in proportion to their concentration.<BR>In summary, arginine-supplemented diets inhibited the growth of Walker 256 carcinosarcoma, probably because of the urea produced with in the tissues of these rats.

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