Electrophysiological Study on the Effect of ATP and Cytochrome C on the Central Nervous System

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  • Cytochrome C と ATP の中枢作用機序に関する比較研究
  • Cytochrome C ト ATP ノ チュウスウ サヨウ キジョ ニ カン

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An electrophysiological study was made in order to clarify the effects of ATP and cytochrome C on the central nervous system of rabbits with the following results.<BR>1. ATP and cytochrome C decreased the threshold of arousal reaction due to the stimulation of the brain stem reticular formation.<BR>2. On the evoked muscular discharge in fore and hind limbs due to the stimulation of the cerebral cortex, cytochrome C showed facilitatory effect stronger than ATP.<BR>3. On the evoked muscular discharge due to the stimulation of the hippocampus, ATP showed facilitatory effect stronger than cytochrome C.<BR>4. On the early components (N1, N2) of afferent average evoked potential in the cerebral cortex due to the stimulation of the sciatic nerve, cytochrome C on one hand showed an inhibitory effect, ATP on the other facilitatory effect.

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