Sulpirideの乳腺刺激作用に関する研究

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書誌事項

タイトル別名
  • Studies on Mammotrophic Action of Sulpiride
  • Sulpirideの乳腺刺激作用に関する研究-2-Sulpirideの乳腺刺激作用機序解析の試み
  • Sulpiride ノ ニュウセン シゲキ サヨウ ニカンスルケンキュウ 2
  • Part II Mechanism of Mammotrophic Action with Sulpiride in Female Rats
  • 第2編 Sulpirideの乳腺刺激作用機序解析の試み

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No mammotrophic action of Sulpiride could be detected on both the hypophysectomized rats injected subcutaneously by either 100mg/kg or 200mg/kg of the drug daily for 2 weeks and the ovariectomized rats injected subcutaneously with 100mg/kg of the drug daily for 2 weeks. Daily injection of Estradio1-17β,10γ, into the hypophysectomized ones could not induce to reveal the action of Sulpiride, but it into the ovariectomized animals could reveal the mammotrophic action of the drug. Bilateral adrenalectomy could not disturbe to reveal the action of Sulpiride.<BR>Radioimmunoassay for prolactin was performed on the serum and pituitary tissue of the diestrous females, which had been checked regular sex cycles in 2 weeks,6,12 and 24 hours after the subcutaneous injection of Sulpiride,100mg/kg. A single dose of the drug elevated the serum prolactin levels to about 3 times that of the controls 6-12 hours after the injection, when the pituitary contents were somewhat lower than that of the controls. The level in serum still elevated about 2.5 times 24 hours after the administration, when the content in the adenohypophysis increased 2 times that of the controls. On the sera of the rats injected daily, prolactin levels went down gradually and returned to normal level more than 7 days after the first injection.<BR>Distribution of the radioactivity were determined on the mammary fatty pad, ovary, adrenal gland, hypophysis, hypothalamus and brain of the rats 1/2,1,3 and 24 hours after the intramuscular injection of 14C-Sulpiride,2mg/kg, respectively. Higher activity in the pituitary tisssues might suggest the direct action of the drug into the adenohypophysis.<BR>In the rabbits, Chlorpromazine induced lower body temperature but Sulpiride,100mg/kg, could not induce lower body temperature in 6 hours after the subcutaneous injection.<BR>In summary, Sulpiride would act the adenohypophysis directly, and induce hypersecretion of prolactin in short time after the administration. Stimulation of prolactin could develope a proliferation with secretion on the mammary glands of the estrogenized animals. On the process of mammotrophic action with Sulpiride, the brain, adrenals and probably hypothalamus might have no direct actions.

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