Electron Microscopic Study of Newborn Rat Brain after Experimental Fetal Anoxia
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- Kasahara Masaru
- Department of Pediatrics Kansai Medical University
Bibliographic Information
- Other Title
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- 周生期低酸素症におけるラット新生仔脳の電顕的研究
- シュウセイキ テイ サンソショウ ニ オケル ラット シンセイシ ノウ ノ デ
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Abstract
In order to investigate a mechanism of perinatal anoxic brain damage the cerebral cortex of newborn rat with anoxic episodes in intrauterine life was examined mainly by using electron microscope.<BR>After anaesthesia induced by intramuscular injection of sodium nembutal, pregnant rats of 18th gestational day were operated on the abdominal wall to expose a small portion of the uterus. Unilateral uterine arteries were clamped by forcets for 2 minutes, and then 1 minute-relaps in clump-free condition was followed. The same procedure was repeated 5 times by means of Nakamura's method.<BR>After the uterus was restored into the abdominal cavity, the abdominal walls were sutured up. Thereafter, the gastation was resumed for the successive 3 days.<BR>Newborn rat brain was cut out and immediately fixed in 2 %glutaraldehyde after birth. The central gyri of the brain tissue was examined by electron microscopy on one day,7 days,2 weeks,3 weeks,4 weeks,5 weeks,6 weeks,7 weeks and 8 weeks after birth, respectively and the following results were obtained.
Journal
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- The Journal of Kansai Medical University
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The Journal of Kansai Medical University 29 (4), 759-786, 1977
The Medical Society of Kansai Medical University
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Details 詳細情報について
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- CRID
- 1390001205458293760
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- NII Article ID
- 130004701185
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- NII Book ID
- AN00046712
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- NDL BIB ID
- 1917566
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- ISSN
- 00228400
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed