Studies on the Effects of Antibiotics on Capillary Permeability

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  • Uba Fumihiko
    First Department of Internal Medicine, Kansai Medical University

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  • 各種抗生物質の血管透過性におよぼす影響
  • 各種抗生物質の血管透過性におよぼす影響-1-各種抗生物質の血管内残留色素量におよぼす影響について
  • カクシュ コウセイ ブッシツ ノ ケッカン トウカセイ ニ オヨボス エイキョ
  • Part II. The Effects of Antibiotics on Dye Concen t rations in Blood Vessels
  • 第1編各種抗生物質の血管内残留色素量におよぼす影響について

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Abstract

Using dyes to observe the influence on capillary permeability produced by antibiotics (CBPC, SBPC, CET, and CEZ administered i. v. at 400 & 9mg/kg) in rats, the changes in dye concentrations in the blood vessels were examined at 5,15,30, and 60 minutes following antibiotic administration in comparison with i. v. NaC1 administration. The results were as follows<BR>1) Using Ev a ns blue 25mg/kg: Evans blue was decreased after antibiotic (400mg/kg) i. v. administration at 5 to 30minutes, markedly so after 5 minutes.<BR>2) Using Evans blue 5mg/kg or Rhodamine B 5mg/kg: These dye concentrations were decreased by antibiotics (400mg/kg)at 5 to 30 minutes, clearly so after 5 minutes, and by antibiotics (9mg/kg) at 5 to 15 minutes, the effects of the latter dosage being weaker than these of the former.<BR>3) The Evans blue concentrations varied with the quantity of phys. NaC1 solution.<BR>4) Using Histamine i. m. and i. v.: Evans blue concentrations were de creased by Histamine i. m. and i. v. at 30 to 60minutes, markedly so after 60 minutes.<BR>5) Using Urokinase i. v.: Urokinase i. v. had no influ ence on dye concentration.

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