Synthesis of Cross-linked Poly (γ-glutamic acid) s by Using a Water-soluble Difunctional Epoxy Compound

DOI

Bibliographic Information

Other Title
  • 水溶性二官能性エポキシ化合物を用いたポリ（γ- グルタミン酸）の水中での架橋反応

Description

Hydro-gel of cross-linked poly (γ-glutanic acid) (γ-PGA) was synthesized by heating a aqueous solution of γ-PGA (pH 4~5.5) in the presence of a small amount of ethylene glycol diglycidyl ether (EGDE) as a cross-linker. Powder samples were obtained by freeze-drying the hydro-gels after neutralization with aqueous sodium bicarbonate solution or without neutralization. Water absorption ratio (weight (g) of absorbed water / weight of dry polymer (g)) of the cross-linked products obtained under the condition of [γ-PGA]/[EGDE]=1/0.05, pH 5.5, at 70 ℃ , for 4 h reached 1200. The obtained powdered samples may be applicable to inhibitors for body organ’s coalescence in surgical sites.

Journal

Details 詳細情報について

  • CRID
    1390001205459698432
  • NII Article ID
    130004648205
  • DOI
    10.11364/networkpolymer.30.136
  • COI
    1:CAS:528:DC%2BD1MXot1Cns74%3D
  • ISSN
    2186537X
    13420577
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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